5-Amino-1MQ: A Premium NNMT Inhibitor for Metabolic Research

5-Amino-1MQ is a groundbreaking small molecule and NNMT inhibitor designed for advanced metabolic research . It functions by selectively inhibiting the enzyme Nicotinamide N-methyltransferase (NNMT), effectively breaking the cycle of metabolic slowdown linked to fat accumulation and supporting energy expenditure . This membrane-permeable compound works at the cellular level to increase NAD+ concentrations and activate sirtuins, making it a highly sought-after research peptide for metabolic and weight management studies .

Key Factual Details

Chemical Name: 5-Amino-1-methylquinolinium iodide (NNMTi) .
Chemical Formula: C₁₀H₁₁IN₂·H₂O (monohydrate salt form) .
Molecular Weight: 159.21 g/mol .
CAS Number: 42464-96-0 .
Purity: Up to 99% (HPLC tested) .
Mechanism: Potent NNMT inhibitor (IC50 = 1.2 μM), increasing NAD+ levels and enhancing cellular energy expenditure without stimulating the central nervous system .
Key Mechanism: Binds selectively to NNMT’s substrate-binding site, helping prevent adipogenesis and promote muscle stem cell regeneration .
Administration: Subcutaneous injection is common in research settings .

Research Dosing

Dosing in research models is highly protocol-specific and not intended for human use. Typical ranges noted in preclinical studies:

Typical Research Dosage: 50 mg to 150 mg per day in cycling protocols (e.g., 4-8 weeks on, 2-4 weeks off) .
Oral Bioavailability: Demonstrates high oral absorption and bioavailability in research models .