Acetyl Hexapeptide-3 (Argireline) – Premium Anti-Wrinkle Research Peptide
Acetyl Hexapeptide-3, commonly known as Argireline, is a synthetic anti-wrinkle peptide that has gained significant attention in cosmetic and neuromuscular research . Often referred to as “Botox in a bottle,” this peptide works by inhibiting neurotransmitter release at the neuromuscular junction, offering a non-invasive approach to studying muscle contraction and wrinkle formation .
Acetyl Hexapeptide-3 (Argireline) – High-Purity Anti-Wrinkle Peptide
Key Factual Details
| ATTRIBUTE | DETAIL |
|---|---|
| Chemical Name | Acetyl Hexapeptide-3 (Argireline, Acetyl Hexapeptide-8) |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ (Ac-EEMQRR-NH₂) |
| Molecular Formula | C₃₄H₆₀N₁₄O₁₂S |
| Molecular Weight | 888.99 g/mol |
| CAS Number | 616204-22-9 |
| Purity | >99% (HPLC verified) |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water |
Mechanism of Action & Research Applications
SNARE Complex Inhibition
Argireline is a biomimetic peptide that structurally mimics the N-terminal end of SNAP-25, a crucial component of the SNARE (Soluble N-ethylmaleimide-sensitive factor activating protein receptor) complex . By competing with native SNAP-25, Argireline destabilizes the SNARE complex, hindering the proper assembly required for vesicle docking and fusion .
Neurotransmitter Release Inhibition
This competitive inhibition impedes the calcium-dependent release of acetylcholine into the synaptic cleft, attenuating muscle cell stimulation . The result is relaxation of facial muscles and reduction in expression lines .
Research Applications:
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Neuromuscular Junction Studies: Investigating neurotransmitter release mechanisms and SNARE complex function
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Cosmetic Research: Evaluating anti-wrinkle efficacy and skin permeability
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Collagen Synthesis Studies: Examining effects on type I collagen fibers and skin tissue architecture
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Cell Proliferation Assays: Assessing antiproliferative effects on cell lines
Research Protocols & Handling
Topical Application Protocol :
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Dosage: Apply a thin layer of 10% emulsion (approximately 2mg per cm²)
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Frequency: Twice daily
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Study Duration: 30 days or until desired outcomes are achieved
Efficacy Data :
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30% wrinkle reduction observed with 5% concentration applied daily for 28 days
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Significant increase in type I collagen fibers in mouse models (P < 0.01)
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IC₅₀ of 34.862 μM in HEK-293 cells
Storage:
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Store lyophilized powder at -20°C
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Reconstituted solutions: store at -80°C for long-term stability
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Stable at room temperature for brief shipping periods
